Retinogeniculate axons undergo eye-specific segregation in the absence of eye-specific layers.

@article{MuirRobinson2002RetinogeniculateAU,
  title={Retinogeniculate axons undergo eye-specific segregation in the absence of eye-specific layers.},
  author={Gianna Muir-Robinson and Bryan J Hwang and Marla B Feller},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 13},
  pages={5259-64}
}
Spontaneous retinal activity mediated by cholinergic transmission regulates the segregation of retinal ganglion cell axons in the lateral geniculate nucleus of the thalamus into eye-specific layers. The details of how the layers form are unknown. Mice lacking the beta2 subunit of the neuronal nicotinic acetylcholine receptor lack ACh-mediated waves and as a result, do not form eye-specific layers at any stage of development. However, during the second postnatal week, beta2-/- mice have… CONTINUE READING
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