Retinogenesis: stochasticity and the competency model.

@article{Barton2015RetinogenesisSA,
  title={Retinogenesis: stochasticity and the competency model.},
  author={Abby Barton and A. J. Fendrik},
  journal={Journal of theoretical biology},
  year={2015},
  volume={373},
  pages={73-81}
}
The vertebrate retina is made up of seven principal cell types. These seven retinal cell types arise from multipotent retinal progenitor cells (RPCs). The competency model was proposed suggesting that RPCs undergo a series of irreversible transitions between competency states, in each of which the RPCs are competent to generate a different subset of cell types, but not retinal cells generated at previous moments. In this work, we generalize the stochastic model of neurogenesis of Barton et al… CONTINUE READING

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