Retinoblastoma regulatory pathway in lung cancer.

  title={Retinoblastoma regulatory pathway in lung cancer.},
  author={Kathryn Wikenheiser-brokamp},
  journal={Current molecular medicine},
  volume={6 7},
Lung cancer is the leading cause of cancer related deaths accounting for more deaths than breast, colon and prostate cancers combined. The Rb-p16 regulatory pathway plays an essential role in tumor suppression in the lung epithelium. This is evidenced by the nearly universal alterations in Rb-p16 pathway components in lung cancer, and the increased incidence of pulmonary carcinomas in persons with germline Rb mutations. Interestingly, p16 loss and Rb mutations preferentially occur in… CONTINUE READING