Retinoblastoma protein represses transcription by recruiting a histone deacetylase

  title={Retinoblastoma protein represses transcription by recruiting a histone deacetylase},
  author={Laura Magnaghi-Jaulin and Regina Groisman and Irina Naguibneva and Philippe Robin and St{\'e}phanie Lorain and J. P. Le Villain and Fr{\'e}d{\'e}ric Troalen and Didier Trouche and Annick Harel-Bellan},
The retinoblastoma tumour-suppressor protein Rb inhibits cell proliferation by repressing a subset of genes that are controlled by the E2F family of transcription factors and which are involved in progression from the G1 to the S phase of the cell cycle. Rb, which is recruited to target promoters by E2F1 (ref. 3), represses transcription by masking the E2F1 transactivation domain and by inhibiting surrounding enhancer elements, an active repression that could be crucial for the proper control… CONTINUE READING
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Hbrm is a downstream target for E 2 F 1 repression by RB

  • A. P. Wolffe, D. Pruss
  • Proc . Natl Acad . Sci . USA
  • 1997

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