Retinoblastoma protein (RB1) controls fate determination in stem cells and progenitors of the mouse male germline.

@article{Yang2013RetinoblastomaP,
  title={Retinoblastoma protein (RB1) controls fate determination in stem cells and progenitors of the mouse male germline.},
  author={Qi-En Yang and Ivy Gwost and Melissa J Oatley and Jon M. Oatley},
  journal={Biology of reproduction},
  year={2013},
  volume={89 5},
  pages={113}
}
Continual spermatogenesis is the cornerstone of male fertility and relies on the actions of an undifferentiated spermatogonial population comprised of stem cells and progenitors. A foundational spermatogonial stem cell (SSC) pool is established during postnatal development that serves as a self-renewing reservoir from which progenitor spermatogonia arise that transiently amplify in number before committing to terminal differentiation. At present, the underlying molecular mechanisms governing… CONTINUE READING