Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages

@article{Iavarone2004RetinoblastomaPD,
  title={Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages},
  author={Antonio Iavarone and Emerson R. King and X W Dai and Gustavo Leone and E Richard Stanley and Anna Lasorella},
  journal={Nature},
  year={2004},
  volume={432},
  pages={1040-1045}
}
In mammals, the fetal liver is the first site of definitive erythropoiesis—the generation of mature, enucleated red cells. The functional unit for definitive erythropoiesis is the erythroblastic island, a multicellular structure composed of a central macrophage surrounded by erythroblasts at various stages of differentiation. Targeted disruption of the retinoblastoma (Rb) tumour suppressor gene in the mouse leads to embryonic death caused by failure of erythroblasts to enucleate. The erythroid… CONTINUE READING
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