Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.

@article{Dbaibo1995RetinoblastomaGP,
  title={Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.},
  author={Ghassan S. Dbaibo and Marina Y. Pushkareva and S. K. Jayadev and James K. Schwarz and Jonathan M. Horowitz and Lina M Obeid and Yusuf A. Hannun},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 5},
  pages={1347-51}
}
Ceramide, a lipid mediator, has been most closely associated with antiproliferative activities. In this study, we examine the mechanism by which ceramide induces growth suppression and the role of the retinoblastoma gene product (Rb) in this process. Withdrawal of serum from the serum-dependent MOLT-4 cells resulted in significant dephosphorylation of Rb, correlating with the induction of G0/G1 cell cycle arrest. Serum withdrawal resulted in marked elevation in the levels of endogenous ceramide… CONTINUE READING