Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.

@article{Kagechika1988RetinobenzoicA1,
  title={Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.},
  author={Hiroyuki Kagechika and Emiko Kawachi and Yuichi Hashimoto and T Himi and Koichi Shudo},
  journal={Journal of medicinal chemistry},
  year={1988},
  volume={31 11},
  pages={2182-92}
}
Two types of aromatic amides, terephthalic monoanilides and (arylcarboxamido)benzoic acids, have been shown to possess potent retinoidal activities and can be classified as retinoids. The structure-activity relationships of these amides are discussed on the basis of differentiation-inducing activity on human promyelocytic leukemia cells HL-60. In generic formula 4 (X = NHCO or CONH), the necessary factors to elicit the retinoidal activities are a medium-sized alkyl group (isopropyl, tert-butyl… CONTINUE READING

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