Retinitis pigmentosa

  title={Retinitis pigmentosa},
  author={D. T. Hartong and E. Berson and T. Dryja},
  journal={The Lancet},
  • D. T. Hartong, E. Berson, T. Dryja
  • Published 2006
  • Medicine
  • The Lancet
  • Hereditary degenerations of the human retina are genetically heterogeneous, with well over 100 genes implicated so far. This Seminar focuses on the subset of diseases called retinitis pigmentosa, in which patients typically lose night vision in adolescence, side vision in young adulthood, and central vision in later life because of progressive loss of rod and cone photoreceptor cells. Measures of retinal function, such as the electroretinogram, show that photoreceptor function is diminished… CONTINUE READING
    429 Citations

    Paper Mentions

    The purpose of this study is to determine the feasibility and safety of adult human bone marrow-derived mesenchymal stem cells by intravitreal injection in patients with retinitis… Expand
    ConditionsRetinitis Pigmentosa
    The objectives of this study are to evaluate the efficacy of Valproic Acid (VPA) to both slow the progression of visual function loss and/or to restore visual function in patients with… Expand
    ConditionsRetinitis Pigmentosa
    Vitamin A and fish oils for retinitis pigmentosa.
    • 27
    General pathophysiology in retinal degeneration.
    • 40
    Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations.
    • 106
    • PDF
    Autosomal recessive retinitis pigmentosa due to ABCA4 mutations: clinical, pathologic, and molecular characterization.
    • 42
    • PDF
    Clinical and Genetic Identification of a Large Chinese Family with Autosomal Dominant Retinitis Pigmentosa
    • 7
    Clinical characteristics and current therapies for inherited retinal degenerations.
    • 96
    • Highly Influenced
    • PDF
    Alterations to retinal architecture prior to photoreceptor loss in a mouse model of retinitis pigmentosa.
    • 22
    • PDF


    Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success
    • 230
    • PDF
    X-linked retinitis pigmentosa. Profile of clinical findings.
    • 117
    Disease progression in patients with dominant retinitis pigmentosa and rhodopsin mutations.
    • 123
    • PDF
    Treatable forms of retinitis pigmentosa associated with systemic neurological disorders.
    • 22
    Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function.
    • 79
    • PDF
    Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness.
    • 240
    • PDF
    Disease expression of RP1 mutations causing autosomal dominant retinitis pigmentosa.
    • 120
    Novel association of RP1 gene mutations with autosomal recessive retinitis pigmentosa
    • 64
    • PDF