Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors.

@article{Farinelli2013RetinitisPO,
  title={Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors.},
  author={Pietro Farinelli and Blanca Arango-Gonz{\'a}lez and Jakob G. J. Voelkl and Ioana S Alesutan and Florian Lang and Eberhart Zrenner and François Paquet-Durand and Per A. R. Ekstr{\"o}m},
  journal={Journal of neurochemistry},
  year={2013},
  volume={127 6},
  pages={868-79}
}
Retinitis Pigmentosa involves a hereditary degeneration of photoreceptors by as yet unresolved mechanisms. The secretable protein α-Klotho has a function related to ageing processes, and α-Klotho-deficient mice have reduced lifespan and declining functions in several tissues. Here, we studied Klotho in connection with inherited photoreceptor degeneration. Increased nuclear immunostaining for α-Klotho protein was seen in degenerating photoreceptors in four different Retinitis Pigmentosa models… CONTINUE READING
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