Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

@article{Ruiz2011RetinaldehydeIA,
  title={Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.},
  author={Francesc Xavier Ruiz and Sergio Port{\'e} and Oriol Gallego and Armando Moro and Albert Ard{\`e}vol and Alberto Del R{\'i}o-Esp{\'i}nola and Carme Rovira and Jaume Farr{\'e}s and Xavier Par{\'e}s},
  journal={The Biochemical journal},
  year={2011},
  volume={440 3},
  pages={335-44}
}
Human AKR (aldo-keto reductase) 1C proteins (AKR1C1-AKR1C4) exhibit relevant activity with steroids, regulating hormone signalling at the pre-receptor level. In the present study, investigate the activity of the four human AKR1C enzymes with retinol and retinaldehyde. All of the enzymes except AKR1C2 showed retinaldehyde reductase activity with low Km values (~1 μM). The kcat values were also low (0.18-0.6 min-1), except for AKR1C3 reduction of 9-cis-retinaldehyde whose kcat was remarkably… CONTINUE READING