Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.

@article{WrightJin2013RetinaldehydeDE,
  title={Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.},
  author={Elizabeth C. Wright-Jin and John R. Grider and Gregg Duester and Robert O Heuckeroth},
  journal={Developmental biology},
  year={2013},
  volume={381 1},
  pages={28-37}
}
The enteric nervous system (ENS) forms from the neural crest-derived precursors that colonize the bowel before differentiating into a network of neurons and glia that control intestinal function. Retinoids are essential for normal ENS development, but the role of retinoic acid (RA) metabolism in development remains incompletely understood. Because RA is produced locally in the tissues where it acts by stimulating RAR and RXR receptors, RA signaling during development is absolutely dependent on… CONTINUE READING