Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism.

  title={Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism.},
  author={F. W. Kiefer and Gabriela Orasanu and Shriram Nallamshetty and Jonathan D Brown and Hong Wang and Philip Luger and Nathan R. Qi and Charles F. Burant and Gregg Duester and Jorge Plutzky},
  volume={153 7},
Recent data link vitamin A and its retinoid metabolites to the regulation of adipogenesis, insulin sensitivity, and glucose homeostasis. Retinoid metabolism is tightly controlled by an enzymatic network in which retinaldehyde dehydrogenases (Aldh1-3) are the rate-limiting enzymes that convert retinaldehyde to retinoic acid. Aldh1a1-deficient mice are protected from diet-induced obesity and hence diabetes. Here we investigated whether Aldh1a1 and the retinoid axis regulate hepatic glucose and… CONTINUE READING


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