Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits.

@article{Scheppke2008RetinalVP,
  title={Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits.},
  author={Lea Scheppke and Edith Aguilar and Ray F. Gariano and Ruth A Jacobson and J. H. Hood and John Doukas and Jon Cao and Glenn Noronha and Shiyin Yee and Sara M. Weis and Michael B. Martin and Richard M Soll and David A. Cheresh and Martin Friedlander},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 6},
  pages={2337-46}
}
Retinal and choroidal vascular diseases, with their associated abnormalities in vascular permeability, account for the majority of patients with vision loss in industrialized nations. VEGF is upregulated in ischemic retinopathies such as diabetes and is known to dramatically alter vascular permeability in a number of nonocular tissues via Src kinase-regulated signaling pathways. VEGF antagonists are currently in clinical use for treating the new blood vessels and retinal edema associated with… CONTINUE READING

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VEGF antagonists are currently in clinical use for treating the new blood vessels and retinal edema associated with neovascular eye diseases , but such therapies require repeated intraocular injections .
VEGF antagonists are currently in clinical use for treating the new blood vessels and retinal edema associated with neovascular eye diseases , but such therapies require repeated intraocular injections .
VEGF antagonists are currently in clinical use for treating the new blood vessels and retinal edema associated with neovascular eye diseases , but such therapies require repeated intraocular injections .
VEGF antagonists are currently in clinical use for treating the new blood vessels and retinal edema associated with neovascular eye diseases , but such therapies require repeated intraocular injections .
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