Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange

@inproceedings{SantosFerreira2016RetinalTO,
  title={Retinal transplantation of photoreceptors results in donor–host cytoplasmic exchange},
  author={Tiago Santos-Ferreira and S{\'i}lvia Llonch and Oliver Borsch and Kai Postel and Jochen Haas and Marius Ader},
  booktitle={Nature communications},
  year={2016}
}
Pre-clinical studies provided evidence for successful photoreceptor cell replacement therapy. Migration and integration of donor photoreceptors into the retina has been proposed as the underlying mechanism for restored visual function. Here we reveal that donor photoreceptors do not structurally integrate into the retinal tissue but instead reside between the photoreceptor layer and the retinal pigment epithelium, the so-called sub-retinal space, and exchange intracellular material with host… CONTINUE READING

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