Retinal toxicity of chloroquine hydrochloride administered by intraperitoneal injection.

@article{Gaynes2008RetinalTO,
  title={Retinal toxicity of chloroquine hydrochloride administered by intraperitoneal injection.},
  author={Bruce Ira Gaynes and Elise Torczynski and Zoltan Varro and Richard Grostern and Jay I Perlman},
  journal={Journal of applied toxicology : JAT},
  year={2008},
  volume={28 7},
  pages={895-900}
}
Chloroquine is quinolone derivative known to exert dose-related retinal toxicity, albeit in a variable manner. It is thought that variability in the presentation of chloroquine retinopathy may be the result of perturbations in drug bioavailability subsequent to oral ingestion. In order to better understand the ramifications of bioavailability on the development of retinal injury subsequent to chloroquine use, this study investigated the relationship between retinal injury and chloroquine… CONTINUE READING