Retinal repair by transplantation of photoreceptor precursors

@article{MacLaren2006RetinalRB,
  title={Retinal repair by transplantation of photoreceptor precursors},
  author={R. MacLaren and R. A. Pearson and A. MacNeil and R. Douglas and T. Salt and M. Akimoto and A. Swaroop and J. Sowden and R. Ali},
  journal={Nature},
  year={2006},
  volume={444},
  pages={203-207}
}
Photoreceptor loss causes irreversible blindness in many retinal diseases. Repair of such damage by cell transplantation is one of the most feasible types of central nervous system repair; photoreceptor degeneration initially leaves the inner retinal circuitry intact and new photoreceptors need only make single, short synaptic connections to contribute to the retinotopic map. So far, brain- and retina-derived stem cells transplanted into adult retina have shown little evidence of being able to… Expand
670 Citations

Paper Mentions

Neurobiology: Right timing for retina repair
  • T. Reh
  • Biology, Medicine
  • Nature
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  • 28
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Restoration of vision after transplantation of photoreceptors
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Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation
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Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina.
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Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.
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The Retinal Pigment Epithelium: a Convenient Source of New Photoreceptor cells?
  • 13
  • PDF
Progenitor Cell Transplantation for Retinal Disease
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Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives
  • 38
  • Highly Influenced
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References

SHOWING 1-10 OF 36 REFERENCES
Survival and differentiation of cultured retinal progenitors transplanted in the subretinal space of the rat.
  • 160
Retinopathy induced in mice by targeted disruption of the rhodopsin gene
  • 503
Incorporation of murine brain progenitor cells into the developing mammalian retina.
  • 109
  • PDF
Differential effect of the rd mutation on rods and cones in the mouse retina.
  • 514
  • PDF
Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors.
  • M. Akimoto, H. Cheng, +12 authors A. Swaroop
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006
  • 293
  • PDF
Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo
  • 76
Nrl is required for rod photoreceptor development
  • 793
  • PDF
...
1
2
3
4
...