Retinal repair by transplantation of photoreceptor precursors

@article{MacLaren2006RetinalRB,
  title={Retinal repair by transplantation of photoreceptor precursors},
  author={Robert E. MacLaren and Rachael A. Pearson and A. MacNeil and Ronald H. Douglas and Thomas E. Salt and Masayuki Akimoto and Anand Swaroop and Jane C. Sowden and Robin R Ali},
  journal={Nature},
  year={2006},
  volume={444},
  pages={203-207}
}
Photoreceptor loss causes irreversible blindness in many retinal diseases. Repair of such damage by cell transplantation is one of the most feasible types of central nervous system repair; photoreceptor degeneration initially leaves the inner retinal circuitry intact and new photoreceptors need only make single, short synaptic connections to contribute to the retinotopic map. So far, brain- and retina-derived stem cells transplanted into adult retina have shown little evidence of being able to… 

Restoration of vision after transplantation of photoreceptors

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The Retinal Pigment Epithelium: a Convenient Source of New Photoreceptor cells?

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Progenitor Cell Transplantation for Retinal Disease

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Subretinal transplantation of MACS purified photoreceptor precursor cells into the adult mouse retina.

Injection of enriched cell suspensions into the subretinal space of adult wild-type mice resulted in a 3-fold higher integration rate compared to unsorted cell suspensions, and magnetic-associated cell sorting (MACS) - enrichment of transplantable rod photoreceptor precursors isolated from the neonatal retina of Photoreceptor-specific reporter mice based on the cell surface marker CD73 is shown.
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