Retinal proteins modified by 4-hydroxynonenal: identification of molecular targets.

@article{Kapphahn2006RetinalPM,
  title={Retinal proteins modified by 4-hydroxynonenal: identification of molecular targets.},
  author={Rebecca J. Kapphahn and Babatomiwa M Giwa and Kristin M Berg and Heidi Roehrich and Xiao Ning Feng and Timothy W. Olsen and Deborah A. Ferrington},
  journal={Experimental eye research},
  year={2006},
  volume={83 1},
  pages={165-75}
}
The reactive aldehyde, 4-hydroxynonenal (HNE), is a product of lipid peroxidation that can covalently modify and inactivate proteins. Previously, we reported increased HNE modification of select retinal proteins resolved by one-dimensional gel electrophoresis in aged Fisher 344 x Brown Norway rats (Louie, J.L., Kapphahn, R.J., Ferrington, D.A., 2002. Proteasome function and protein oxidation in the aged retina. Exp. Eye Res. 75, 271-284). In the current study, quantitative assessment of HNE… CONTINUE READING
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