Retinal protection from acute glaucoma-induced ischemia-reperfusion injury through pharmacologic induction of heme oxygenase-1.


PURPOSE To investigate the protective effects of cobalt protoporphyrin (CoPP), a potent heme oxygenase (HO)-1 inducer, in a rat model of ischemia-reperfusion injury and to document the possible antiapoptotic and anti-inflammatory mechanisms underlying the protection. METHODS Rats pretreated with intraperitoneal injection of CoPP (5 mg/kg) were subjected… (More)
DOI: 10.1167/iovs.09-4086


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