Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation.

@article{Warfvinge2005RetinalPC,
  title={Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation.},
  author={Karin Warfvinge and Jens Folke Kiilgaard and Erin B Lavik and Erik Scherfig and Robert Langer and Henry J. Klassen and Michael Joseph Young},
  journal={Archives of ophthalmology},
  year={2005},
  volume={123 10},
  pages={
          1385-93
        }
}
OBJECTIVE To investigate the survival, integration, and differentiation of mouse retinal progenitor cells after transplantation to the subretinal space of adult pigs. METHODS Green fluorescent protein-positive (GFP+) murine retinal progenitor cells were transplanted subretinally as single cells, spheres, or biodegradable polymer-progenitor composites into 24 nonimmunosuppressed adult pigs. Of these, 14 pigs received laser lesions (n = 11) or outer retinal scraping injury (n = 3). Recipients… CONTINUE READING
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