Retinal pigment epithelium cells promote the maturation of monocytes to macrophages in vitro.

@article{Osusk1997RetinalPE,
  title={Retinal pigment epithelium cells promote the maturation of monocytes to macrophages in vitro.},
  author={Roman Osusk{\'y} and Pankaj Malik and Stephen J. Ryan},
  journal={Ophthalmic research},
  year={1997},
  volume={29 1},
  pages={31-6}
}
Proliferative vitreoretinopathy is characterized by excessive cell proliferation within the eye; retinal pigment epithelial (RPE) cells form the majority of proliferating cells and interact with infiltrating leukocytes including monocytes. The purpose of this study was to determine the effect of RPE cells on the maturation of monocytes to macrophages. The enriched monocyte fraction of peripheral blood mononuclear cells was either cultured with or without RPE cells. The expression of the… CONTINUE READING