Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization

Abstract

To test the hypothesis that increased Rap1a activity specifically in retinal pigment epithelial cells resists choroidal neovascularization (CNV), self-complementary adeno-associated virus 2 (scAAV2) with RPE65-promoter-driven GFP vectors were generated and introduced subretinally into Rap1b-deficient mice. Six-week-old mice that received subretinal control… (More)
DOI: 10.1038/mtm.2016.56

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@inproceedings{Wang2016RetinalPE, title={Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization}, author={Haibo Wang and Xiaokun Han and Colin Andrew Bretz and Silke Becker and Deeksha Gambhir and George D. Smith and R. Jude Samulski and Erika S. Wittchen and Lawrence A. Quilliam and Magdalena Chrzanowska-Wodnicka and M E Hartnett}, booktitle={Molecular therapy. Methods & clinical development}, year={2016} }