Retinal pigment epithelial acid lipase activity and lipoprotein receptors: effects of dietary omega-3 fatty acids.

@article{Elner2002RetinalPE,
  title={Retinal pigment epithelial acid lipase activity and lipoprotein receptors: effects of dietary omega-3 fatty acids.},
  author={Victor Maurice Elner},
  journal={Transactions of the American Ophthalmological Society},
  year={2002},
  volume={100},
  pages={
          301-38
        }
}
PURPOSE To show that fish oil-derived omega-3 polyunsaturated fatty acids, delivered to the retinal pigment epithelium (RPE) by circulating low-density lipoproteins (LDL), enhance already considerable RPE lysosomal acid lipase activity, providing for more efficient hydrolysis of intralysosomal RPE lipids, an effect that may help prevent development of age-related macular degeneration (ARMD). METHODS Colorimetric biochemical and histochemical techniques were used to demonstrate RPE acid lipase… CONTINUE READING

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CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 258 REFERENCES

Acid lipase: a histochemical and biochemical study using triton X100-naphtyl palmitate micelles.

  • The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1978
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

The Ultrastructure of the Retinal Pigment Epithelium with Observations on the Choriocapillaris and Bruch's Membrane.

  • Transactions of the American Ophthalmological Society
  • 1963
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Dietary fat and risk for advanced age-related macular degeneration.

  • Archives of ophthalmology
  • 2001
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin.

  • Investigative ophthalmology & visual science
  • 2001
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Prospective study of dietary fat and the risk of age-related macular degeneration.

  • The American journal of clinical nutrition
  • 2001
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin.

  • Investigative ophthalmology & visual science
  • 1999
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Structure, function and disease of retinal epithelium

MF Marmor
  • 1997
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Structure, function and disease of retinal epithelium

MF Marmor
  • 1997
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL