Retinal organization in the bcl-2-overexpressing transgenic mouse.

  title={Retinal organization in the bcl-2-overexpressing transgenic mouse.},
  author={Enrica Strettoi and Maila Volpini},
  journal={The Journal of comparative neurology},
  volume={446 1},
Naturally occurring cell death is believed to play a major role during the development of the nervous system in the establishment of neuronal architecture. Here we study the effects of cell death inhibition by using a transgenic mouse in which the powerful antiapoptotic gene bcl-2 is expressed in neurons. The retina of this mouse reveals that the general neuronal plan has been maintained. However, bcl-2 overexpression leads to altered frequencies of the major cell types in the retina. Thus, it… CONTINUE READING

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