Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

@article{Sohn2016RetinalNM,
  title={Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus},
  author={E. Sohn and H. V. van Dijk and C. Jiao and P. Kok and Woojin Jeong and N. Demirkaya and Allison Garmager and F. Wit and M. Kucukevcilioglu and M. V. van Velthoven and J. DeVries and R. Mullins and M. Kuehn and R. Schlingemann and M. Sonka and F. Verbraak and M. Abr{\`a}moff},
  journal={Proceedings of the National Academy of Sciences},
  year={2016},
  volume={113},
  pages={E2655 - E2664}
}
Significance Diabetic retinopathy (DR), a primary cause of blindness, is characterized by microvascular abnormalities. Recent evidence suggests that retinal diabetic neuropathy (RDN) also occurs in people with diabetes, but little is known about the temporal relationship between DR and RDN. This longitudinal study in people with diabetes with no or minimal DR shows that RDN precedes signs of microvasculopathy and that RDN is progressive and independent of glycated hemoglobin, age, and sex. This… Expand
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