Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis.

@article{GordonLipkin2007RetinalNF,
  title={Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis.},
  author={Eliza M. Gordon-Lipkin and BettyAnn Chodkowski and Daniel S Reich and Seth A. Smith and Mathew Pulicken and Laura Joan Balcer and Elliot M. Frohman and Gary R. Cutter and Peter A. Calabresi},
  journal={Neurology},
  year={2007},
  volume={69 16},
  pages={1603-9}
}
OBJECTIVE Optical coherence tomography (OCT) noninvasively quantifies retinal nerve fiber layer (RNFL) thickness. Studies show RNFL thinning in multiple sclerosis (MS), and we assessed its association with brain atrophy. METHODS RNFL thickness was measured in 40 patients with MS and 15 controls. Brain parenchymal fraction (BPF) and partial brain volumes were estimated from cranial MRI scans using SIENA-X. Multiple linear regression modeling assessed the association between OCT and MRI… CONTINUE READING