Retinal lipid and glucose metabolism dictates angiogenesis through lipid sensor Ffar1

@inproceedings{Joyal2016RetinalLA,
  title={Retinal lipid and glucose metabolism dictates angiogenesis through lipid sensor Ffar1},
  author={Jean-Sebastien Joyal and Ye Sun and Marin L. Gantner and Zhuo Shao and Lucy P. Evans and Nicholas J. Saba and Thomas W. Fredrick and Samuel B Burnim and Jin Sung Kim and Gauri Patel and Aimee M. Juan and Christian G. Hurst and Colman J. Hatton and Zhenghao Cui and Kerry A Pierce and Patrick Bh{\'e}rer and Edith Aguilar and Michael B. Powner and Kristis Vevis and Michel R Boisvert and Zhongjie Fu and {\'E}mile L{\'e}vy and Marcus Fruttiger and Alan B Packard and Flavio Astolpho Vieira Souto Rezende and Bruno Maranda and Przemyslaw Sapieha and Jinghua Chen and Martin Friedlander and Clary B Clish and Lois E. Smith},
  booktitle={Nature Medicine},
  year={2016}
}
Tissues with high metabolic rates often use lipids, as well as glucose, for energy, conferring a survival advantage during feast and famine. Current dogma suggests that high-energy–consuming photoreceptors depend on glucose. Here we show that the retina also uses fatty acid β-oxidation for energy. Moreover, we identify a lipid sensor, free fatty acid receptor 1 (Ffar1), that curbs glucose uptake when fatty acids are available. Very-low-density lipoprotein receptor (Vldlr), which is present in… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 51 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Fashioning blood vessels by ROS signalling and metabolism.

Seminars in cell & developmental biology • 2018
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Starvation in man.

Clinics in endocrinology and metabolism • 1976
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…