Retinal lipid and glucose metabolism dictates angiogenesis through lipid sensor Ffar1

  title={Retinal lipid and glucose metabolism dictates angiogenesis through lipid sensor Ffar1},
  author={Jean-Sebastien Joyal and Ye Sun and Marin L. Gantner and Zhuo Shao and Lucy P. Evans and Nicholas J. Saba and Thomas W. Fredrick and Samuel B Burnim and Jin Sung Kim and Gauri Patel and Aimee M. Juan and Christian G. Hurst and Colman J. Hatton and Zhenghao Cui and Kerry A Pierce and Patrick Bh{\'e}rer and Edith Aguilar and Michael B. Powner and Kristis Vevis and Michel R Boisvert and Zhongjie Fu and {\'E}mile L{\'e}vy and Marcus Fruttiger and Alan B Packard and Flavio Astolpho Vieira Souto Rezende and Bruno Maranda and Przemyslaw Sapieha and Jinghua Chen and Martin Friedlander and Clary B Clish and Lois E. Smith},
  booktitle={Nature Medicine},
Tissues with high metabolic rates often use lipids, as well as glucose, for energy, conferring a survival advantage during feast and famine. Current dogma suggests that high-energy–consuming photoreceptors depend on glucose. Here we show that the retina also uses fatty acid β-oxidation for energy. Moreover, we identify a lipid sensor, free fatty acid receptor 1 (Ffar1), that curbs glucose uptake when fatty acids are available. Very-low-density lipoprotein receptor (Vldlr), which is present in… CONTINUE READING
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