Retinal ischemic preconditioning in the rat: requirement for adenosine and repetitive induction.

@article{Li1999RetinalIP,
  title={Retinal ischemic preconditioning in the rat: requirement for adenosine and repetitive induction.},
  author={Bifang Li and Steven Roth},
  journal={Investigative ophthalmology & visual science},
  year={1999},
  volume={40 6},
  pages={
          1200-16
        }
}
PURPOSE A brief period of ischemia can induce a remarkably complete state of ischemic tolerance in the retina, a phenomenon known as ischemic preconditioning (IPC). The mechanisms of IPC were studied in the rat retina by examining the role of adenosine as a possible mediator and determining whether IPC protection could be induced more than once in the same rat. METHODS Retinal ischemia was produced for 60 minutes in ketamine-xylazine-anesthetized Sprague-Dawley rats, and recovery was measured… CONTINUE READING

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