Retinal implants: emergence of a multidisciplinary field.

@article{Dagnelie2012RetinalIE,
  title={Retinal implants: emergence of a multidisciplinary field.},
  author={Gislin Dagnelie},
  journal={Current opinion in neurology},
  year={2012},
  volume={25 1},
  pages={
          67-75
        }
}
  • G. Dagnelie
  • Published 1 February 2012
  • Medicine
  • Current opinion in neurology
PURPOSE OF REVIEW This review summarizes the current status of retinal prostheses, recent accomplishments, and major remaining research, engineering, and rehabilitation challenges. RECENT FINDINGS Retinal research, materials and biocompatibility studies, and clinical trials in patients blind from retinitis pigmentosa are representative of an emerging field with considerable promise and sobering challenges. A summary of progress in dozens of laboratories, companies, and clinics around the… 
A wide-field suprachoroidal retinal prosthesis is stable and well tolerated following chronic implantation.
TLDR
A wide-field retinal prosthesis was stable and well tolerated during long-term suprachoroidal implantation in a cat model and the surgical approach was reproducible and overall safe.
Attaining higher resolution visual prosthetics: a review of the factors and limitations.
TLDR
This review will outline and critically compare major current approaches to visual prosthetics, and in particular retinal prosthetics and engage in an in-depth discussion of the limitations imposed by current technology, physics, and the underlying biology of the retina.
Retinal prosthesis that incorporates the organization of the nerve fibre layer
  • T. Fitzgibbon
  • Biology, Medicine
    Clinical & experimental ophthalmology
  • 2017
TLDR
By extending the stimulation area well beyond the fovea and stimulating the nerve fibre layer, axons from any remaining ganglion cells in more peripheral regions of the retina (low acuity) can be used to generate a visuotopic map.
The functional performance of the Argus II retinal prosthesis
TLDR
This review will discuss the performance of the Argus II in restoring sight to the blind, and shed light on its expected developments in the coming years.
The effect of stimulation electrode array size on the temperature of the retinal tisssue in visual prostheses
  • M. Celik, I. Karagoz
  • Medicine
    2014 22nd Signal Processing and Communications Applications Conference (SIU)
  • 2014
TLDR
It is shown that visual percepts, called phosphene, are obtained via stimulation of remaining nerve cells in the literature and it is observed that the temperature has the highest values near the stimulation electrode array and it has a decremental tendency away from there.
Characterization of a Polymer‐Based, Fully Organic Prosthesis for Implantation into the Subretinal Space of the Rat
TLDR
The results demonstrate that the device implanted in nondystrophic eyes is well tolerated, highly biocompatible, and suitable as retinal prosthesis in case of photoreceptor degeneration.
The Effect of the Electrical Stimulation on Temperature Rise in the Retinal Tissue for Visual Prostheses
TLDR
A model is created to investigate thermal influence of an implant placed internal surface of the retinal tissue and solution is made using finite element analysis and it is shown that the temperature rise has highest value near the stimulation electrode and its surroundings in the case of using the model with thermal insulation.
Proceedings of the First International Optogenetic Therapies for Vision Symposium.
TLDR
There is a lot of interest in optogenetics as a pan-disease clinical treatment for end-stage application in the inherited degenerative diseases of the retina, but research to date has been limited to nonhuman clinical studies.
...
...

References

SHOWING 1-10 OF 92 REFERENCES
Development of a surgical approach for a wide-view suprachoroidal retinal prosthesis: evaluation of implantation trauma
TLDR
A large stimulation array can be reliably inserted into the suprachoroidal space without trauma to the neuroretina and these findings suggest that this is an appropriate surgical approach for the placement of an electrode array for use in retinal stimulation.
Implantation and explantation of a wireless epiretinal retina implant device: observations during the EPIRET3 prospective clinical trial.
TLDR
The EPIRET3 system can be successfully implanted and explanted in patients with blindness and RP and the surgical steps are feasible, and the postoperative follow-up disclosed an acceptable range of adverse events.
Retinal Prosthesis
TLDR
The recent clinical trials are reviewed and technology breakthroughs that will contribute to next generation of retinal prostheses are highlighted.
Preoperative Candidate Evaluations for Retinal Prosthesis Trials
TLDR
The preoperative evaluations of candidates are addressed that may provide insight into selecting potential candidates for retinal prosthetic devices and the preparation of early recipients.
Psychophysical evaluation for visual prosthesis.
  • G. Dagnelie
  • Medicine, Psychology
    Annual review of biomedical engineering
  • 2008
TLDR
The functional assessment, and particularly on psychophysical methodology, is addressed, but also other measures of safety and efficacy, as well as approaches to vision rehabilitation with visual prostheses are addressed.
Restoration of useful vision up to letter recognition capabilities using subretinal microphotodiodes
TLDR
Promising results from some patients where the retinal tissue above the chip was functional and the implant fulfilled its expected function are presented and an approximation of how the visual perceptions might have appeared to the subjects is presented, based on a mathematical model and patient reports.
Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials.
TLDR
Single percepts induced by single-electrode stimulation were relatively small, but the form of percepts, especially after multielectrodestimulation, often did not match the stimulation pattern, even in a normal-sighted volunteer.
Preliminary 6 month results from the argustm ii epiretinal prosthesis feasibility study
  • M. Humayun, J. Dorn, R. Greenberg
  • Medicine
    2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 2009
TLDR
Preliminary results show that the Argus II system provides some functional vision to blind subjects.
Testing of semichronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa.
TLDR
Semichronic implantation of a microelectrode-STS system showed that it was safe and remained functional for at least 4 weeks in two patients with advanced RP.
Retinal remodeling in the Tg P347L rabbit, a large‐eye model of retinal degeneration
TLDR
It is shown that disease progression in the TgP347L rabbit closely tracks human cone‐sparing RP, including the cone‐associated preservation of bipolar cell signaling and triggering of reprogramming, which makes it an excellent model for gene therapy, cell biological intervention, progenitor cell transplantation, surgical interventions, and bionic prosthetic studies.
...
...