Retinal homeobox genes and the role of cell proliferation in cavefish eye degeneration.

@article{Strickler2002RetinalHG,
  title={Retinal homeobox genes and the role of cell proliferation in cavefish eye degeneration.},
  author={Allen G. Strickler and Kuburat Famuditimi and William R Jeffery},
  journal={The International journal of developmental biology},
  year={2002},
  volume={46 3},
  pages={285-94}
}
The teleost Astyanax mexicanus exhibits eyed surface dwelling (surface fish) and blind cave dwelling (cavefish) forms. Despite lacking functional eyes as adults, cavefish embryos form eye primordia, which later arrest in development, degenerate and sink into the orbit. We are comparing the expression patterns of various eye regulatory genes during surfacefish and cavefish development to determine the cause of eye degeneration. Here we examine Rx and Chx/Vsx family homeobox genes, which have a… CONTINUE READING