Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease.

@article{Williams2013RetinalGC,
  title={Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease.},
  author={P Andrew Williams and Rebecca A Thirgood and Huw Oliphant and Aura Frizzati and Elinor Littlewood and Marcela Votruba and Mark A. Good and Julie Williams and James E. Morgan},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 7},
  pages={1799-806}
}
Retinal ganglion cells (RGCs) may be regarded as a target biomarker in Alzheimer's disease (AD). We therefore explored the possibility that RGC degeneration, rather than cell loss, is an early marker of neuronal degeneration in a murine model of AD. RGC dendritic morphology and dendritic spine densities of CA1 hippocampal pyramidal neurons were quantified in 14-month-old transgenic mice expressing the APP(SWE) (amyloid precusor protein-Swedish mutation) mutation (Tg2576). The dendritic… CONTINUE READING

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