Retinal ganglion cell degeneration in Alzheimer's disease.

  title={Retinal ganglion cell degeneration in Alzheimer's disease.},
  author={Janet C. Blanks and David R Hinton and Alfredo Arrigo Sadun and Carol Ann Miller},
  journal={Brain research},
  volume={501 2},
This study documents the light-microscopic and ultrastructural characteristics of ganglion cell degeneration in the retinas of patients with Alzheimer's disease (AD). The results show degeneration in the retinal ganglion cells (RGCs) characterized by a vacuolated, 'frothy' appearance of the cytoplasm. The degeneration is unique in AD because of the absence of neurofibrillary tangles within the RGCs, or of neuritic plaques or amyloid angiopathy in the retinas or optic nerves of any of the cases… CONTINUE READING
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