Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies.

@article{Kuehn2005RetinalGC,
  title={Retinal ganglion cell death in glaucoma: mechanisms and neuroprotective strategies.},
  author={Markus H. Kuehn and John H. Fingert and Young H. Kwon},
  journal={Ophthalmology clinics of North America},
  year={2005},
  volume={18 3},
  pages={383-95, vi}
}
Various cellular and molecular mechanisms that may lead to apoptotic cell death of retinal ganglion cells in glaucoma are discussed. These cellular mechanisms include neurotrophic factor deprivation, ischemia, glial cell activation, glutamate excitotoxicity, and abnormal immune response. Based on experimental and clinical evidence, the rationale for various neuroprotective strategies is described. 

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