Retinal ganglion cell axotomy induces an increase in intracellular superoxide anion.

@article{Lieven2006RetinalGC,
  title={Retinal ganglion cell axotomy induces an increase in intracellular superoxide anion.},
  author={Christopher J. Lieven and Mark J. Hoegger and Christopher R Schlieve and Leonard A Levin},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 4},
  pages={
          1477-85
        }
}
PURPOSE Retinal ganglion cells (RGCs) undergo apoptosis after axonal injury. The time course of cell death is variable and depends in part on the degree of injury sustained. Decreasing reactive oxygen species (ROS) levels or shifting the redox state to reduction promotes the survival of RGCs in tissue culture after axotomy. It was hypothesized that a specific ROS, superoxide anion, acts as an intracellular signaling molecule for RGC death after axotomy. METHODS Intracellular superoxide levels… CONTINUE READING

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