Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix.

@article{Guo2005RetinalGC,
  title={Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix.},
  author={Li Guo and Stephen E Moss and Robert A. Alexander and Robin R Ali and Frederick W. Fitzke and Maria Francesca Cordeiro},
  journal={Investigative ophthalmology & visual science},
  year={2005},
  volume={46 1},
  pages={
          175-82
        }
}
PURPOSE To investigate the effect of IOP on retinal ganglion cell (RGC) apoptosis and correlate the effects with IOP-induced changes in extracellular matrix (ECM) in the retina and optic nerve head (ONH) in glaucomatous rat eyes. METHODS Thirty-seven Dark Agouti rats had elevated IOP induced in the left eye by hypertonic saline episcleral vein injections. Eyes were examined at 3 months histologically for RGC apoptosis and expression of specific ECM components. RESULTS RGC apoptosis was… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 165 CITATIONS, ESTIMATED 70% COVERAGE

Matrix metalloproteinase-9 expression in retinal ganglion cell layer and effect of topically applied brimonidine tartrate 0.2% therapy on this expression in an endothelin-1-induced optic nerve ischemia model

Zeynep Aktas, Gokhan Gurelik, +3 authors Berati Hasanreisoglu
  • International Ophthalmology
  • 2009
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Protective effects of curcumin on ischemic reperfusion of rat retina

  • Comparative Clinical Pathology
  • 2019
VIEW 3 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2005
2019

CITATION STATISTICS

  • 10 Highly Influenced Citations

  • Averaged 14 Citations per year from 2017 through 2019

  • 9% Increase in citations per year in 2019 over 2018

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

Pressure related apoptosis in neuronal cell lines.

  • Journal of neuroscience research
  • 2000
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 4 EXCERPTS

Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats.

  • Investigative ophthalmology & visual science
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL