Retinal functional development is sensitive to environmental enrichment: a role for BDNF

@article{Landi2007RetinalFD,
  title={Retinal functional development is sensitive to environmental enrichment: a role for BDNF},
  author={Silvia Landi and Alessandro Sale and Nicoletta Berardi and Alessandro Viegi and Lamberto Maffei and Maria Cristina Cenni},
  journal={The FASEB Journal},
  year={2007},
  volume={21},
  pages={130 - 139}
}
Retina has long been considered less plastic than cortex or hippocampus, the very sites of experience‐dependent plasticity. Now, we show that retinal development is responsive to the experience provided by an enriched environment (EE): the maturation of retinal acuity, which is a sensitive index of retinal circuitry development, is strongly accelerated in EE rats. This effect is present also in rats exposed to EE up to P10, that is before eye opening, suggesting that factors sufficient to… 
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Retinal Plasticity
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Examples of hippocampal and cortical paradigms of plasticity and of retinal structural rearrangements found in organization and circuitry following altered developmental conditions or occurrence of genetic diseases leading to neuronal degeneration are reviewed.
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