Retinal function and CFH-ARMS2 polymorphisms analysis: a pilot study in Italian AMD patients.

@article{Capoluongo2012RetinalFA,
  title={Retinal function and CFH-ARMS2 polymorphisms analysis: a pilot study in Italian AMD patients.},
  author={Ettore Capoluongo and Paola Concolino and Marco Piccardi and Dario Marangoni and Enrica Mello and Angelo Maria Minnella and Cristina M Savastano and Antonello Fadda and Cecilia Zuppi and Silvia Bisti and Benedetto Falsini},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 8},
  pages={1852.e5-12}
}
Two major susceptibility genes, complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2), have been implicated in age-related macular degeneration (AMD) pathogenesis. We analyzed the association between CFH rs1061170 and/or ARMS2 rs10490924 polymorphisms with central retinal function properties, as evaluated by focal electroretinogram (fERG). Forty early AMD patients, with preserved visual acuity and typical macular lesions, underwent fERG recording (in response to 41 Hz… CONTINUE READING
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