• Biology, Medicine
  • Published in Molecular vision 2010

Retinal ectopias and mechanically weakened basement membrane in a mouse model of muscle-eye-brain (MEB) disease congenital muscular dystrophy

@inproceedings{Hu2010RetinalEA,
  title={Retinal ectopias and mechanically weakened basement membrane in a mouse model of muscle-eye-brain (MEB) disease congenital muscular dystrophy},
  author={Huaiyu Hu and Joseph E Candiello and Peng Zhang and Sherry L. Ball and David Alan Cameron and Willi Halfter},
  booktitle={Molecular vision},
  year={2010}
}
PURPOSE Some forms of congenital muscular dystrophy are associated with cortical and retinal dysplasias. Protein O-mannose N-acetylglucosaminyltransferase 1 (POMGnT1) knockout mice, one of the mouse models of muscular dystrophy, exhibit a thinner retina with reduced density of retinal ganglion cells. This study is aimed to further characterize the knockout retina, with special emphasis on the inner limiting membrane, the basement membrane of the retina. METHODS Immunofluorescence staining and… CONTINUE READING

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