Retinal degeneration in the rd mouse in the absence of c-fos.

@article{Hafezi1998RetinalDI,
  title={Retinal degeneration in the rd mouse in the absence of c-fos.},
  author={Farhad Hafezi and Mathias H. Abegg and Christian Grimm and Andreas Wenzel and Karlheinz Munz and J{\"u}rg St{\"u}rmer and Debora B Farber and Charlotte E. Rem{\'e}},
  journal={Investigative ophthalmology & visual science},
  year={1998},
  volume={39 12},
  pages={
          2239-44
        }
}
PURPOSE Apoptosis is the final common death pathway of photoreceptors in light-induced retinal degeneration and in several animal models for retinal dystrophy. To date, little is known about gene regulation of apoptosis in the retina. The expression of the immediate early gene c-fos is upregulated concomitant with apoptosis in light-induced photoreceptor degeneration and in the rd mouse, an animal model for inherited retinal degeneration. In a recent study it was shown that c-Fos is essential… CONTINUE READING

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