Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision

Abstract

Membrane lipid composition is central to the highly specialized functions of neurological tissues. In the retina, abnormal lipid metabolism causes severe forms of blindness, often through poorly understood neuronal cell death. Here, we demonstrate that deleting the de novo lipogenic enzyme fatty acid synthase (FAS) from the neural retina, but not the… (More)
DOI: 10.1172/jci.insight.97076

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