Retinal control on the axial length mediated by transforming growth factor-beta in chick eye.

  title={Retinal control on the axial length mediated by transforming growth factor-beta in chick eye.},
  author={Shigenori Honda and Seishiro Fujii and Yoshibumi Sekiya and Masahiro Yamamoto},
  journal={Investigative ophthalmology & visual science},
  volume={37 12},
PURPOSE To clarify retinal control on scleral growth in form-deprivation myopia (FDM) in the chick, the authors studied change in transforming growth factor-beta (TGF-beta) in the form-deprived eye and the effect of this growth factor on scleral cell proliferation and axial length. METHODS Change in TGF-beta in FDM in the chick was measured by reverse transcriptase polymerase chain reaction (RT-PCR), immunoblot, and immunohistochemistry. The effect of TGF-beta on [3H]thymidine uptake of… CONTINUE READING


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