Retinal changes in the Tg-SwDI mouse model of Alzheimer’s disease

  title={Retinal changes in the Tg-SwDI mouse model of Alzheimer’s disease},
  author={Fred G. Oliveira-Souza and Marci L. DeRamus and Thomas van Groen and Alexis E. Lambert and Mark Bolding and Christianne E. Strang},
Alzheimer's disease (AD), a debilitating neurodegenerative illness, is characterized by neuronal cell loss, mental deficits, and abnormalities in several neurotransmitter and protein systems. AD is also associated with visual disturbances, but their causes remain unidentified. We hypothesize that the visual disturbances stem from retinal changes, particularly changes in the retinal cholinergic system, and that the etiology in the retina parallels the etiology in the rest of the brain. To test… CONTINUE READING