Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta.

@article{Sugita2006RetinalAC,
  title={Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta.},
  author={Sunao Sugita and Yuri Futagami and Sylvia B. Smith and Hany A Naggar and Manabu Mochizuki},
  journal={Experimental eye research},
  year={2006},
  volume={83 6},
  pages={1459-71}
}
The ocular microenvironment is immunosuppressive and anti-inflammatory. Pigment epithelial (PE) cells isolated from the eye possess a new property of suppressing T cell receptor-dependent activation of T cells in vitro. This property depends on their capacity to produce cell-surface and soluble inhibitory molecules. The iris pigment epithelia (IPE) do so through direct cell-to-cell contact with naïve T cells, and this suppressive contact is mediated by interactions between B7 and membrane-bound… CONTINUE READING

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