Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs.

@article{Li2016RetinalAC,
  title={Retinal and choroidal expression of BMP-2 in lens-induced myopia and recovery from myopia in guinea pigs.},
  author={Honghui Li and Juan Wu and Dongmei Cui and Junwen Zeng},
  journal={Molecular medicine reports},
  year={2016},
  volume={13 3},
  pages={
          2671-6
        }
}
The present study investigated the retinal and choroidal expression of bone morphogenetic protein-2 (BMP-2) in myopia and in myopia recovery in a guinea pig model. For this investigation, two groups of guinea pigs, lens‑induced myopia and recovery from myopia, were used, and defocused myopia was induced the guinea pigs wearing ‑4.00 D lenses on the right eyes for 3 weeks, with the left eyes serving as the contralateral. In the following week, the lenses of the guinea pigs in the recovery group… 
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A multi-scale computational model is proposed to simulate eye development based on the assumption that scleral growth is controlled by genetic factors while sCleral remodeling is driven by genetic Factors and the eye’s refractive error, and is the first model that distinguishes sclal growth from remodeling.
Modeling Myopia in Guinea Pigs
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Guinea pigs have emerged as a popular mammalian model because of the relative ease of housing and husbandry, larger eyes, and better visual acuity compared to other laboratory rodents, but the nature of the defocus stimuli and their effects on retinal image quality are still unknown.
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The structure of BMP-2, its activation and regulation signaling pathways, B MP-2 clinical applications, and limitations of using BMP -2 as a therapeutic are focused on.
SWATH Based Quantitative Proteomics Reveals Significant Lipid Metabolism in Early Myopic Guinea Pig Retina
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This study serves as the first report to detect and confirm novel retinal protein changes and significant biological functions in the early LIM mammalian guinea pigs through an integrated discovery and targeted proteomic approach.
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The Influence of Genetics in Myopia Control: A Pilot Study
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The result of lens therapies for myopia control could vary depending on genetic variants, and significant differences were found between the rs235770…rs1881492 and rs23 5770–rs1656404 polymorphisms.
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