Retinal and choroidal TGF-beta in the tree shrew model of myopia: isoform expression, activation and effects on function.

@article{Jobling2009RetinalAC,
  title={Retinal and choroidal TGF-beta in the tree shrew model of myopia: isoform expression, activation and effects on function.},
  author={Andrew I Jobling and Ran Wan and Alex Gentle and Bang V. Bui and Neville A. Mcbrien},
  journal={Experimental eye research},
  year={2009},
  volume={88 3},
  pages={458-66}
}
A visually evoked signalling cascade, which begins in the retina, transverses the choroid, and mediates scleral remodelling, is considered to control eye growth. The ubiquitous cytokine TGF-beta has been associated with alterations in ocular growth, where alterations in scleral TGF-beta isoforms mediate the scleral remodelling that results in myopia. However, while the TGF-beta isoforms have been implicated in the scleral change during myopia development, it is unclear whether alterations in… CONTINUE READING
Highly Cited
This paper has 93 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Changes of TGF-β2, MMP-2, and TIMP-2 levels in the vitreous of patients with high myopia

Graefe's Archive for Clinical and Experimental Ophthalmology • 2014
View 4 Excerpts
Highly Influenced

The multifunctional choroid

Progress in Retinal and Eye Research • 2010
View 3 Excerpts
Highly Influenced

94 Citations

02040'10'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 94 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Making sense of latent TGFbeta activation.

Journal of cell science • 2003
View 3 Excerpts
Highly Influenced

Expression of bFGF and TGF-beta 2 in experimental myopia in chicks.

Investigative ophthalmology & visual science • 1995
View 5 Excerpts
Highly Influenced

Cloning , expression , and characterization of chicken transforming growth factor beta 4

B. A. Pfeffer, K. C. Flanders, C. J. Guerin, D. Danielpour, D. H. Anderson
Biochem . Biophys . Res . Commun . • 1994
View 8 Excerpts
Highly Influenced

Intraocular CNTF reduces vision in normal rats in a dose-dependent manner.

Investigative ophthalmology & visual science • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…