Retinal and choroidal TGF-beta in the tree shrew model of myopia: isoform expression, activation and effects on function.

  title={Retinal and choroidal TGF-beta in the tree shrew model of myopia: isoform expression, activation and effects on function.},
  author={Andrew I Jobling and Ran Wan and Alex Gentle and Bang V. Bui and Neville A. Mcbrien},
  journal={Experimental eye research},
  volume={88 3},
A visually evoked signalling cascade, which begins in the retina, transverses the choroid, and mediates scleral remodelling, is considered to control eye growth. The ubiquitous cytokine TGF-beta has been associated with alterations in ocular growth, where alterations in scleral TGF-beta isoforms mediate the scleral remodelling that results in myopia. However, while the TGF-beta isoforms have been implicated in the scleral change during myopia development, it is unclear whether alterations in… CONTINUE READING
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