Retinal age pigments generated by self-assembling lysosomotropic detergents

A UNIVERSAL biomarker of cellular ageing in eukaryotic postmitotic cells is the appearance over time of autofluorescent lysosomal residual bodies called age pigments or lipofuscin granules1. Their role in the process of cellular ageing has been debated without resolution2. Neither the identity nor mechanism of formation of the fluorophores has been… CONTINUE READING