Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat.

@article{Fielden2015RetinalTI,
  title={Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat.},
  author={M. R. Fielden and Jonathan A Werner and Jeff A Jamison and Aldo Coppi and Dean Hickman and Robert T. Dunn and Esther Trueblood and Lei Zhou and Cynthia A. Afshari and Ruth M Lightfoot-Dunn},
  journal={Toxicologic pathology},
  year={2015},
  volume={43 4},
  pages={581-92}
}
β-Secretase 1 (BACE1) represents an attractive target for the treatment of Alzheimer's disease. In the course of development of a novel small molecule BACE1 inhibitor (AMG-8718), retinal thinning was observed in a 1-month toxicity study in the rat. To further understand the lesion, an investigational study was conducted whereby rats were treated daily with AMG-8718 for 1 month followed by a 2-month treatment-free phase. The earliest detectable change in the retina was an increase in… CONTINUE READING
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