Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography

@article{Zeng2016RetinalSA,
  title={Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography},
  author={Yong Zeng and Ronald S. Petralia and Camasamudram Vijayasarathy and Zhijian Wu and Suja Hiriyanna and Hongman Song and Ya‐Xian Wang and Paul A. Sieving and Ronald A. Bush},
  journal={Investigative Ophthalmology \& Visual Science},
  year={2016},
  volume={57},
  pages={OCT277 - OCT287}
}
Purpose Spectral-domain optical coherence tomography (SD-OCT) was used to characterize the retinal phenotype, natural history, and treatment responses in a mouse model of X-linked retinoschisis (Rs1-KO) and to identify new structural markers of AAV8-mediated gene therapy outcome. Methods Optical coherence tomography scans were performed on wild-type and Rs1-KO mouse retinas between 1 and 12 months of age and on Rs1-KO mice after intravitreal injection of AAV8-scRS/IRBPhRS (AAV8-RS1). Cavities… 

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