Retinal Pigmented Epithelium Barrier

  title={Retinal Pigmented Epithelium Barrier},
  author={Lawrence J Rizzolo},
The outer blood–retinal barrier is formed by the retinal pigment epithelium in collaboration with choroidal capillaries. The barrier requires the coordinated action of the pumps and channels that mediate transcellular transport and the tight junctions that mediate diffusion across the paracellular space. Tight junctions are semi-selective barriers that retard the diffusion of some solutes more than others; these junctions are also very dynamic. Their permeability and selectivity can be… CONTINUE READING