Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG versus AQP4-IgG Optic Neuritis: A Cohort Study

@article{StiebelKalish2017RetinalNF,
  title={Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG versus AQP4-IgG Optic Neuritis: A Cohort Study},
  author={H. Stiebel-Kalish and I. Lotan and J. Brody and G. Chodick and O. Bialer and R. Marignier and M. Bach and M. Hellmann},
  journal={PLoS ONE},
  year={2017},
  volume={12}
}
Background Optic neuritis (ON) in patients with anti-myelin oligodendrocyte glycoprotein (MOG)-IgG antibodies has been associated with a better clinical outcome than anti-aquaporin 4 (AQP4)- IgG ON. Average retinal nerve fiber layer thickness (RNFL) correlates with visual outcome after ON. Objectives The aim of this study was to examine whether anti-MOG-IgG ON is associated with better average RNFL compared to anti-AQP4-IgG ON, and whether this corresponds with a better visual outcome. Methods… Expand

Paper Mentions

Observational Clinical Trial
In eight ophthalmic units, the investigator will include all inflammatory optic neuritis (ON) during acute phase and rank them in two groups: 1/ ON with autoantibodies anti… Expand
ConditionsOptic Neuritis
InterventionOther
Aquaporin-4 IgG seropositivity is associated with worse visual outcomes after optic neuritis than MOG-IgG seropositivity and multiple sclerosis, independent of macular ganglion cell layer thinning
TLDR
AQP4-IgG seropositivity is associated with worse visual outcomes after ON compared with MOG-ON and MS-ON, even with similar severity of macular GCIPL thinning. Expand
AQP4-IgG and MOG-IgG Related Optic Neuritis—Prevalence, Optical Coherence Tomography Findings, and Visual Outcomes: A Systematic Review and Meta-Analysis
TLDR
AQP4-IgG- and MOG-IGG-associated disease are important diagnostic considerations in adults presenting with isolated ON, especially in Asian populations. Expand
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TLDR
The visual acuity in MOG-on patients was as good as Seronegative-ON patients, whereas the RNFL of the optic nerve head showed a significant thinning as in the AQP4-ON Patients. Expand
Differences in morphology and visual function of myelin oligodendrocyte glycoprotein antibody and multiple sclerosis associated optic neuritis
TLDR
This study found significantly worse visual acuity at nadir, but better recovery and thinner global peripapillary retinal nerve fiber layer thickness in MOG-ON patients compared to multiple sclerosis associated ON and healthy controls. Expand
Unfavorable Structural and Functional Outcomes in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Optic Neuritis
TLDR
The severity and pattern of retinal and optic nerve damage closely resembled phenotypes commonly observed in AQP4-seropositive rON without fulfilling current diagnostic criteria for NMOSD. Expand
Retinal nerve fiber layer thickness in optic neuritis with MOG antibodies: A systematic review and meta-analysis
TLDR
This meta-analysis aimed to systematically review current literature measuring the thickness of retinal nerve fiber layer (RNFL) in patients with myelin oligodendrocyte glycoprotein antibodies (MOG-ab) associated optic neuritis and showed that the degree of RNFL loss in Mog-ab-positive optic neuritas patients may not differ from that of AQP4-ab patients. Expand
Comparison of spontaneous brain activity revealed by regional homogeneity in AQP4-IgG neuromyelitis optica-optic neuritis versus MOG-IgG optic neuritis patients: a resting-state functional MRI study
TLDR
AQP4-IgG+NMO-ON and MOG-IGG+ON subjects showed abnormal synchronized neuronal activity in many brain regions, which is consistent with deficits in visual, motor, and cognitive function. Expand
Aquaporin-4 and Myelin Oligodendrocyte Glycoprotein Autoantibody Status Predict Outcome of Recurrent Optic Neuritis.
TLDR
The aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) immunoglobulin G (IgG) serostatus and visual outcomes in patients with recurrent optic neuritis (rON) initially seeking treatment are determined. Expand
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis in Canada
TLDR
MOG-IgG ON in Canada has a variable presentation with most patients having substantial initial vision loss with good recovery, and this is the largest characterization of the disease in Canada to date. Expand
Optical coherence tomography in central nervous system demyelinating diseases related optic neuritis.
TLDR
Thinning of superior and inferior quadrants of RNFL are more commonly seen in MOG-IgG+ON and AQP4-IGG+ on, whereas the structural change from OCT is comparable. Expand
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References

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MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients
TLDR
Retinal neuro-axonal damage and visual impairment after ON in MOG-IgG-positive patients are as severe as in AQP4-IGG- positive NMOSD patients. Expand
Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis
TLDR
The combination of two predictors, the absence of magnetic resonance imaging brain abnormalities and a higher lesion extent score, showed a good ability to discriminate between an autoantibody-associated ON (MOG or AQP4) and MS. Expand
MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study
TLDR
The diagnostic utility of the anti-MOG assay was evaluated and the MRI and OCT findings of anti- MOG+ and anti-AQP4+ patients with isolated ON were compared. Expand
Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis
TLDR
MOG antibodies have a strong association with BON and may be a useful clinical biomarker, and Class II evidence that MOG antibodies are associated with AQP4 antibody–negative BON is provided. Expand
Antibodies to MOG and AQP4 in adults with neuromyelitis optica and suspected limited forms of the disease
TLDR
MOG-ab identify a subgroup of adult patients with NMO, LETM and ON that have better outcome than those associated with AQP4-ab and the follow-up of titres does not correlate with outcome. Expand
Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders
TLDR
Patients with NMOSD with MOG antibodies have distinct clinical features, fewer attacks, and better recovery than patients with AQP4 antibodies or patients seronegative for both antibodies. Expand
Myelin injury without astrocytopathy in neuroinflammatory disorders with MOG antibodies
TLDR
It is suggested that anti-MOG+ cases are distinct from MS and anti-AQP4+ NMOSD, and CSF pleocytosis, high protein levels, and oligoclonal IgG band negativity distinguished the anti-mog+ cases from MS patients. Expand
MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome
TLDR
The predominantly relapsing and often severe disease course and the short median time to second attack support the use of prophylactic long-term treatments in patients with MOG-IgG-positive ON and/or myelitis; however, treatment failure leading to rapid accumulation of disability was noted in many patients as well as flare-ups after steroid withdrawal. Expand
Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype
TLDR
4 patients with an NMO/NMOSD phenotype who had antibodies to MOG appear to have more favorable clinical outcomes than those with typical AQP4 antibody–mediated disease, and MOG antibody titers fell in all 4 patients. Expand
Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid
TLDR
This study validates the concept of the intrinsic effect of autoantibody against surface antigens and offers a model for testing antibody and astrocyte-targeted therapies in NMO, and establishes a link between motor-deficit, NMO-like lesions andAstrocytopathy mediated by intrathecal AQP4-IgG. Expand
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